Antibody found to block COVID-19 virus 100% in experiments #coronavirusnewstolive - May 17, 2020 29 0 COMMENTS
New Delhi: US-based Sorrento Therapeutics has introduced that an antibody has demonstrated its capacity to utterly block SARS-CoV-2 an infection of wholesome cells in preclinical laboratory experiments.
SARS-CoV-2 is the virus answerable for the COVID-19 pandemic.
The outcomes on Friday confirmed that Sorrento’s anti-SARS-CoV-2 antibody, STI-1499, utterly neutralised the virus infectivity at a really low antibody dose, making it a first-rate candidate for additional testing and improvement.
Initial biochemical and biophysical analyses additionally point out STI-1499 is a probably sturdy antibody drug candidate, mentioned the antibody-centric biopharmaceutical firm headquartered in San Diego, California.
“Our STI-1499 antibody shows exceptional therapeutic potential and could potentially save lives following receipt of necessary regulatory approvals,” Henry Ji, Chairman and CEO of Sorrento, mentioned in a press release.
“We at Sorrento are working day and night to complete the steps necessary to get this product candidate approved and available to the waiting public.”
Sorrento goals to generate an antibody cocktail product that might act as a “protective shield” in opposition to SARS-CoV-2 coronavirus an infection and stay efficient even when virus mutations render a single antibody remedy much less efficient over time.
The firm has been screening billions of antibodies and has up to now recognized tons of of antibody candidates that bind the S1 subunit of the SARS-CoV-2 Spike protein.
Approximately one dozen of those antibodies have demonstrated the flexibility to block the S1 protein’s interplay with human angiotensin-converting enzyme 2 (ACE2), the receptor used for viral entrance into human cells, Sorrento mentioned.
These blocking antibodies have been additional examined in an in vitro SARS-CoV-2 virus an infection mannequin pursuant to a preclinical testing settlement for COVID-19 therapeutic candidates that was beforehand introduced on March 31.
Among the antibodies exhibiting neutralizing exercise, the antibody, STI-1499, stood out for its capacity to utterly block SARS-CoV-2 an infection of wholesome cells in the experiments.
Sorrento mentioned STI-1499 will probably be the primary antibody in the antibody cocktail (COVI-SHIELD) it’s growing.
STI-1499 can also be anticipated to be developed as a stand-alone remedy, (COVI-GUARD) due to the excessive efficiency it has exhibited in experiments to date.