Among sufferers with coronavirus illness 2019 (COVID-19) who expertise stomach ache and diarrhea, there’s a vital chance of Helicobacter pylori (H pylori) an infection, in accordance to the outcomes of a examine printed in the Journal of Pediatric Gastroenterology and Nutrition.1
It is presently understood that extreme acute respiratory syndrome coronavirus-2 (SARS-CoV-2), binds angiotensin-changing enzyme-2 (ACE-2) receptors.2 These receptors are extremely expressed in the gut, suggesting that SARS-CoV-2 an infection might lead to gastrointestinal signs amongst sufferers with COVID-19.
As H pylori will increase ACE-2 receptor expression in the gastrointestinal tract, a bunch of researchers in Turkey performed an investigation from June 1, 2020, to July 20, 2020 to decide the consequences of H pylori on the scientific presentation and course of COVID-19 infections.1
Patients who have been COVID-19 optimistic, confirmed by way of polymerase chain response, have been included in the evaluation. Stool samples have been collected and the presence of H pylori was decided by way of antigen screening checks.
A complete of 108 sufferers (imply age, 49.54 years) have been included in the evaluation: 77 sufferers examined adverse for H pylori an infection and 31 sufferers examined optimistic. Compared with sufferers who examined adverse, sufferers with H pylori an infection had considerably extra frequent stomach ache (P =.007) and diarrhea (P =.006). However, COVID-19 severity, outcomes of the illness, and the variety of hospitalized days weren’t considerably related to H pylori an infection.
The investigators famous that the affiliation between H pylori an infection and stomach ache and diarrhea in sufferers with COVID-19 is mediated by ACE-2 receptors. “[T]here is an urgent need for studies investigating the presence of H pylori and the expression of ACE-2 receptors in the lungs and upper respiratory system,” the investigators famous.1
- Balamtekin N, Artuk C, Arslan M, Gülşen M. The effect of Helicobacter pylori on the presentation and clinical course of coronavirus disease 2019 infection. JPGN. 2021;72(4):511-513. doi: 10.1097/MPG.0000000000003005
- Lan J, Ge J, Yu J, et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 2020;581(7807):215–220. doi. 10.1038/s41586-020-2180-5
This article initially appeared on Gastroenterology Advisor