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Among sufferers with coronavirus illness 2019 (COVID-19) who expertise stomach ache and diarrhea, there’s a vital chance of Helicobacter pylori (H pylori) an infection, in accordance to the outcomes of a examine printed in the Journal of Pediatric Gastroenterology and Nutrition.1

It is presently understood that extreme acute respiratory syndrome coronavirus-2 (SARS-CoV-2), binds angiotensin-changing enzyme-2 (ACE-2) receptors.2 These receptors are extremely expressed in the gut, suggesting that SARS-CoV-2 an infection might lead to gastrointestinal signs amongst sufferers with COVID-19.

As H pylori will increase ACE-2 receptor expression in the gastrointestinal tract, a bunch of researchers in Turkey performed an investigation from June 1, 2020, to July 20, 2020 to decide the consequences of H pylori on the scientific presentation and course of COVID-19 infections.1

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Patients who have been COVID-19 optimistic, confirmed by way of polymerase chain response, have been included in the evaluation. Stool samples have been collected and the presence of H pylori was decided by way of antigen screening checks.

A complete of 108 sufferers (imply age, 49.54 years) have been included in the evaluation: 77 sufferers examined adverse for H pylori an infection and 31 sufferers examined optimistic. Compared with sufferers who examined adverse, sufferers with H pylori an infection had considerably extra frequent stomach ache (P =.007) and diarrhea (P =.006). However, COVID-19 severity, outcomes of the illness, and the variety of hospitalized days weren’t considerably related to H pylori an infection.

The investigators famous that the affiliation between H pylori an infection and stomach ache and diarrhea in sufferers with COVID-19 is mediated by ACE-2 receptors. “[T]here is an urgent need for studies investigating the presence of H pylori and the expression of ACE-2 receptors in the lungs and upper respiratory system,” the investigators famous.1


  1. Balamtekin N, Artuk C, Arslan M, Gülşen M. The effect of Helicobacter pylori on the presentation and clinical course of coronavirus disease 2019 infection. JPGN. 2021;72(4):511-513. doi: 10.1097/MPG.0000000000003005
  2. Lan J, Ge J, Yu J, et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptorNature. 2020;581(7807):215–220. doi. 10.1038/s41586-020-2180-5

This article initially appeared on Gastroenterology Advisor

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